The salivary glands are small structures in the head and neck, but can give rise to a wide variety of benign and. Image were created or taken from wikimedia commons i. T rise within sg tissue, common parotid 78% composed of cellular elements oncocytes. Treatment and cure of salivary gland neoplasms requires surgical intervention in most cases. Histogenesis of benign pleomorphic adenoma mixed tumor. Benign tumors tumor we re more common in submandibular gland. The morphological classification of salivary gland tumors is based upon the publications of the who 1 and the armed forces institute of pathology. S100 protein and myoepithelial neoplasms the journal of. Apr 16, 2020 there are three common types of malignant salivary gland neoplasm. Its of keen interest that all benign tumors arise from major salivary glands whereas on the other side all malignant arise from minor salivary glands. Benign neoplasms of salivary glands i webpathology. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
In tumors originating from intercalated ducts, myoepithelial cells may assume one of two roles. Ppt salivary gland neoplasms powerpoint presentation. If you continue browsing the site, you agree to the use of cookies on this website. Files are available under licenses specified on their description page. The annual incidence of salivary gland cancers ranges from 0.
Despite efforts to identify new parameters to improve their diagnosis and therapy, little progress in the management of. T o access free multiple choice questions on this topic. Introduction saliva is a clear, alkaline, somewhat viscid secretion from the parotid, submandibular, sublingual and smaller mucous glands of the mouth. Disease bioinformatics research of salivary gland neoplasms has been linked to neoplasms, carcinoma, salivary gland diseases, mixed salivary gland tumor, adenoma. Current concepts in diagnosis of unusual salivary gland tumors. Pathology outlines primary salivary gland neoplasms. All structured data from the file and property namespaces is available under the creative commons cc0 license. Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. Benign neoplasm of major salivary glands the webs free icd. Salivary gland tumours are rare and have very wide histological. Histopathologic grading of salivary gland neoplasms has been done with various degrees of success and hence various degrees of acceptance. Histogenesis and classification based on 186 cases lymphoepithelial lesions of salivary glands. Salivary gland neoplasms have always been an field of interest for head neck and tumors because of its diversity in histogenesis and morphogenesis.
Mucoepidermoid carcinomas are rare salivary gland type tumors that. Ten patients with recurrent, metastatic, or unresectable salivary gland tumors. This is a short video on the most common neoplasms tumors and cancers of the salivary glands. Salivary gland neoplasms, arising in major or minor salivary and mucous glands, constitute a very heterogeneous group of tumours. Because of the scarcity of such lesions, little is known about the efficacy of chemotherapy for advanced salivary gland cancers. Still in the us, carcinomas of the major salivary glands comprise 11% of oropharyngeal neoplasms. Salivary gland tumors are relatively rare and constitute 3% to 4% of all head and neck neoplasms. Salivary gland tumors of the lip jama otolaryngologyhead. Benign tumour polymorphous low grade adenocarcinoma plga rare lesion 23% of benign s. Histogenetic and morphogenetic concepts of salivary gland. Some observations on salivary secretion and fluid absorption by mouth.
They occur over a wide age range but the peak incidence is in 6th to 7th decades with a slight female predominance. Salivary gland neoplasm an overview sciencedirect topics. Current status of histogenetic and morphogenetic concepts. Salivary gland tumours are rare and most cases are referred to the head and neck clinic. A free powerpoint ppt presentation displayed as a flash slide show on id. With respect to salivary gland pleomorphic adenomas, light microscopic and ultrastructural studies indicate. This contribution should be read in conjunction with non neoplastic disease of the salivary glands, page 173. The majority of these neoplasms are benign 80% and only 20% are malignant. Pdf histogenesis of salivary gland neoplasms shaleen. Fnac is a simple quick inexpensive and minimally invasive technique to. Histogenesis and classification based on 186 cases bernier, joseph l bhaskar, surindar n.
Role of fineneedle aspiration cytology in the diagnosis of. Because most salivary gland neoplasms are benign, they most likely account for 1% to 2% of head and neck malignancies. Salivary gland tumors account for fewer than 3% of neoplasms of the head and neck. Histopathologic grading of salivary gland neoplasms. Reason for the above criteria can be understood only when a complete knowledge and understanding. Tumors mostly involve the major salivary glands, 42. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. Histogenesis of salivary gland pleomorphic adenoma mixed tumor with an evaluation of the role of the myoepithelial cell. It can be used to monitor the presence and levels of hormones, drugs, antibodies, microorganisms and ions. For a long time, differences in opinion with regard to the histogenesis of these lesions as well as the difficulties encountered in differentiating.
Thompson salivary glands for dummies 1 salivary gland neoplasms lester d. Gene expression screening of salivary gland neoplasms. Malignant salivary gland neoplasms are rare, representing approximately 3% to 7% of all head and neck cancers. The salivary glands are classified as major or minor. The incidence of salivary gland cancers is estimated at approximately 2. Circadian rhythms in human salivary flow rate and composition. Sox10 is a novel marker of acinus and intercalated duct.
Current state of knowledge on salivary gland cancers ncbi. The ucla experience with minor salivary gland tumors of the lip is presented and contrasted with that of the literature. Synchronous multiple unilateral parotid gland tumors of benign and. For parotid neoplasms, the most common surgical procedure performed is the superficial parotidectomy with facial nerve preservation. A sound knowledge of the local and regional anatomy is essential to minimize morbidity.
Newlands, md, phd 62602 salivary gland neoplasms benign neoplasms malignant neoplasms controversial issues. The fine anatomical and histological details will be covered in other courses. However, you should know the locations and characteristics of the salivary glands. Although the majority of minor salivary gland tumors are malignant, three fourths of parotid tumors are benign. Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain com. Lung carcinomas of the salivary gland type are also known as salivary glandtype tumors of the lung sgttls or bronchial gland neoplasms the usual consignation to the group of nonsmall cell lung cancer nsclc may be unfortunate because the clinical behavior of sgttls can be quite different from that of conventional lung cancers 5. Salivary gland neoplasms are rare, yet histologically diverse, posing a diagnostic challenge to many practicing pathologists. Salivary gland anatomy n parotid gland n submandibular gland n sublingual gland n minor glands it is not our intent to cover anatomy during this course. Ultrastructural study of the histogenesis of salivary.
Epidermal cysts are common skin lesions but they occur very rarely in the oral cavity, especially in the salivary glands. Salivary gland tumors are relatively uncommon and account for approximately 36% of all neoplasms of the head and neck. Histogenesis of salivary gland pleomorphic adenoma mixed. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The anatomy and physiology of salivary glands benefits of saliva is that it is easily available for noninvasive collection and analysis. To our knowledge, such tumors in this site have not been reported. Advances in diagnosis and management of salivary gland. The study of salivary gland neoplasms has been mentioned in research publications which can be found using our bioinformatics tool below. Batsakis jg, regezi ja, luna ma, elnaggar a 1989 histogenesis of salivary gland neoplasms.
Review of salivary gland neoplasms pubmed central pmc. The etiology of salivary gland tumors sgts remains mostly unknown. Evolving concepts and new entities in the 2017 who classification of salivary gland tumors. The current world health organization who 4th edition of head and neck tumors recognizes 31 types of unique salivary gland epithelial neoplasms, including 20 malignant and 11 benign entities. Pleomorphic adenoma common benign tumor and muc tumor.
This contribution should be read in conjunction with non neoplastic disease of the salivary glands. Mar 28, 2016 this is a short video on the most common neoplasms tumors and cancers of the salivary glands. In an attempt to explain the histogenesis of salivary gland tumors, a bicellular theory of origin has been presented. Mortality from malignant salivary gland neoplasms varies by stage and pathology, but the overall 5year survival rate is 72%. Keywords acinic cell carcinoma 4 pathology 4 salivary glands 4 therapy 4. Salivary gland tumors sgts are rare neoplasms accounting for 0. He two case reports of patients with lung tumors that will be presented are believed to be genuine examples of mixed tumors of salivary gland type presenting as primary lesions of the bronchus. Contrasting from the more common mucosal head and neck cancers. The following anatomical sites found in the table of neoplasms apply to this code given the correct histological behavior.
We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. Lung carcinomas of the salivary gland type radiology. Salivary gland neoplasms constitute a wide variety of benign and malignant tumors. Fnac diagnosis of major salivary gland neoplasms aids in proper planning of required surgery and avoidance of the same in cases of nonneoplastic lesions. Mar 18, 2019 the incidence of salivary gland neoplasms as a whole is approximately 5. Crtc1maml2 fusion transcript in high grade mucoepidermoid. Evolving concepts and new entities in the 2017 who. May 22, 2015 these glands are generally not subjected to incisional or core needle biopsy, because of the possible risks of fistula formation and tumor seedling. Benign neoplasms of the salivary glands clinical gate. Malignant sgts represent 6% of head and neck cancers and 0. Malignant neoplasms of the salivary glands clinical gate. Feb 16, 2012 salivary gland tumours are rare and most cases are referred to the head and neck clinic.
The authors have chosen to begin with the salivary glands, and in this report they present a concept of histogenesis and classification as well as an analysis of 1 salivarygland tumors in children, 2 the relationship between breast carcinoma and salivary. These glands are composed of a number of different types of cells, and unregulated growth of these cells causes neoplasms. Histogenesis of salivary gland neoplasms dwivedi n, agarwal a. The incidence of benign to malignant tumors of the lip does not follow the inverse relationship stated in the axiom that the smaller the salivary gland the greater the probability that a developing tumor will be malignant. Malignant salivary gland neoplasms represent approximately 3% to 7% of all head and neck cancers making them extremely rare tu mors. The majority 70% of salivary gland tumors arise in the parotid gland. Neoplasms of the salivary glands account for about 5% of all tumors of the head and neck, and cancers are even less common. In some tumors of the salivary glands, myoepithelial cells do not participate in histogenesis.
This chapter will provide an overview of the functions of saliva, the anatomy and. Current thinking on malignant salivary gland neoplasms. This theory is supported by indirect evidence from light and electron microscopy. Because of their complexity and relative infrequency, salivary gland tumors commonly result in diagnostic problems. Mar 18, 2019 neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below.
A salivary gland neoplasm is an abnormal growth of the cells constituting the salivary glands. Unlike most cases of head and neck cancer, salivary gland carcinomas are not associated with tobacco exposure. The marginal part of the solid mass included warthin tumor cells. Salivary gland neoplasms account for approximately 3% to 7% of head and neck tumors.
Histogenesis of salivary gland neoplasms dwivedi n. Click here to download free android application for this. Twentytwo benign pleomorphic adenomas of the major salivary glands were studied by transmission electron microscopy and immunohistochemical techniques three cases in order to characterize the cell types comprising the epithelial and socalled. Salivary gland neoplasms according to study report represent less than 3% of all tumors. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma pa is the most common tumor affecting it. Salivary glands primary salivary gland neoplasms classification. The treatment for primary neoplasms of the salivary glands is surgical excision with or without adjunctive radiotherapy. The problem is compounded by the ability of these cells to differentiate and modify. Pages in category salivary gland neoplasia the following 17 pages are in this category, out of 17 total. Thompson salivary glands for dummies 14 carcinoma expleomorphic adenoma prognostic factors pathologic stage size histologic grade and type proportion of carcinoma extent of invasion ki67 labeling index canalicular adenoma benign salivary gland neoplasm composed of bilayered strands of basaloid cells that branch and anastomose to form variably. Some types of neoplasms have malignant characteristics, meaning that they can infiltrate into surrounding structures and can spread to distant regions, whereas others are. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the.
Salivary gland tumors are one of the most complex and relatively rare group of lesions encountered in oral pathology practice. At least two theories of tumorigenesis have been proposed for salivary gland neoplasms. Our primary salivary gland tumors were composed of 22 mecs, 11 warthins tumors, 10 adenoid cystic carcinomas, two basaloid carcinomas, five salivary duct carcinomas. Introduction to salivary glands university of michigan. Review of the major and minor salivary glands, part 2. The majority of these neoplasms are benign and only 20% are malignant.
The current world health organization who 4th edition of head and neck tumors recognizes 31 types of unique salivary gland epithelial neoplasms, including 20 malignant and 11. Crtc1maml2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and warthins tumors. The tumors can arise in about 80% in parotid gland, 15% in submandibular gland and 5% in the sublingual and minor salivary gland. Etiologic factors for major salivary gland cancer include exposure to lowdose radiation while. Jcm free fulltext characteristics of 5015 salivary gland. Their complexity is attributed to heterogeneity of the cells of origin of these lesions. This is a very rare benign neoplasm, that makes up about 1% of all salivary gland tumors, or about 4% of all benign salivary gland tumors. Pdf histogenetic and morphogenetic concepts of salivary.
Among the 5015 salivary gland neoplasms, 3998 80% were benign and 1017 20% were malignant. Salivary gland neoplasms are uncommon lesions 1,2,3 characterized by widely varied phenotypic features and unpredictable clinical outcomes. The goal of this lecture is to focus on a selection of the common tumors of the salivary gland and illustrate their expected morphologic variability. Although surgery and irradiation are the mainstays of treatment, patients with recurrent tumors and those with unresectable or metastatic cancer are not candidates for this usual approach. Implications for histogenesis and biologic behavior. Update in salivary gland pathology university of utah. Malignant neoplasms of the major and minor salivary glands are rare, comprising approximately 3% of all head and neck malignancies. The classification of salivary gland neoplasms can be difficult due to the morphologic overlap between tumor types and the variability in patterns that frequent many of the tumors. The major salivary glands consist of the parotid, submandibular, and sublingual glands. Very few cases have been reported in the literature and, here, we present one such rare case of epidermal cyst in the right parotid gland in a 62yearold female patient. Diseases of salivary gland free download as powerpoint presentation. Salivary gland tumors are a diverse group of neoplasms in terms of both morphology and clinical. This study describes the clinicopathological features and immunohistochemical expression of ki67 and p53 in 60 cases of submandibular salivary. Differentiating between these neoplasms often relies on taking a sample of the tumor, and understanding what salivary gland the neoplasm originated in, as certain types of malignant neoplasms more frequently arise in certain locations.
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